(2006). [19][21], The proposed mechanism of action refers to the Kinsey dual control model of sexual response. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell My Info | Ad Choices  [4] She graduated from Marymount University in Virginia. [5], Eckert began her career with Merck, before moving on to work with smaller, specialty pharmaceutical companies Dura and Elan. She subsequently founded The Pink Ceiling which invests in companies founded by, or delivering products for, women. [1] Eckert works with a team of women to determine which female-led companies will be the recipients of venture capital funding. [1], She sold Sprout to Valeant in 2015 after the company won FDA approval for the drug Addyi, the first drug designed to enhance female libido. Cindy Eckert (formerly Whitehead) is an American entrepreneur who built and sold two pharmaceutical companies, notably Sprout Pharmaceuticals, creator of “female Viagra,” for more than $1B. Two years later, in an unprecedented move, our CEO Cindy Eckert and her shareholders re-acquired Sprout. 5 Disclosed Funding Rounds $99,095,777. Terms & Conditions. [5] After a stint with QVC, Eckert returned to the healthcare space to found two pharmaceutical companies - Slate Pharmaceuticals and Sprout Pharmaceuticals - both of which she sold. We will get this right for women. [37], Even the Score, a coalition of women's group's brought together by a Sprout consultant, actively campaigned for the approval of flibanserin. [32][33][34] Sprout expected to resubmit the New Drug Application (NDA) in the 3rd quarter of 2014. 4th ed. Ahead of the votes, Boehringer Ingelheim had mounted a publicity campaign to promote the controversial disorder of "hypoactive sexual desire". [7], Eckert established an investment firm called The Pink Ceiling in 2016 after the most recent exit, when she sold Sprout Pharmaceuticals to Valeant Pharmaceuticals for $1 billion. Flibanserin, sold under the trade name Addyi, is a medication approved for the treatment of pre-menopausal women with hypoactive sexual desire disorder (HSDD). [35][36] On August 18, 2015 the FDA approved Addyi (Flibanserin) for the treatment of premenopausal women with low sexual desire that causes personal distress or relationship difficulties. Slate sold in 2011 to Actient Pharmaceuticals. The side effects of dizziness, sleepiness, and nausea occur about three to four times more often. All information on this site is provided "as-is" for informational purposes only and is not a substitute for medical advice or treatment. ADDYI is a prescription medicine used to treat hypoactive (low) sexual desire disorder (HSDD) in women who have not gone through menopause, who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation, or the sexual partner. [3], In 2018, Eckert formally changed her name from Cindy Whitehead. On June 18, 2010, a federal advisory panel to the US Food and Drug Administration (FDA) unanimously voted against recommending approval of flibanserin, citing an inadequate risk-benefit ratio. [27] Earlier in the week, a FDA staff report also recommended non-approval of the drug. "[45] An editorial in JAMA noted that, "Although flibanserin is not the first product to be supported by a consumer advocacy group in turn supported by pharmaceutical manufacturers, claims of gender bias regarding the FDA’s regulation have been particularly noteworthy, as have the extent of advocacy efforts ranging from social media campaigns to letters from members of Congress". The majority of adverse events were mild to moderate. [4][5] The certainty of the estimate is low. [7], Eckert established an investment firm called The Pink Ceiling in 2016 after the most recent exit, when she sold Sprout Pharmaceuticals to Valeant Pharmaceuticals for $1 billion. FORTUNE may receive compensation for some links to products and services on this website. [10], Eckert launched the Pink Ceiling in order to improve access to capital for female-led start-ups. Sprout Pharmaceuticals serves customers in the United States. [1] “The injustice I’m fighting with the Pink Ceiling is not only women’s limited access to capital, but also their limited access to mentors,” she told Entrepreneur Magazine. The current brand name is Addyi. In December 2013, a Formal Dispute Resolution was filed,[32] which contained the requirements of the FDA for further studies. Two years later, Sprout was reestablished with our CEO Cindy Eckert back at the helm. The dual control model: The role of sexual inhibition & excitation in sexual arousal and behavior In Janssen, E. (Ed). The Pink Ceiling's incubator - dubbed The Pinkubator - is based in Raleigh, NC. [8] In November 2017, Eckert re-acquired Sprout Pharmaceuticals from Valeant for "almost nothing", according to Bloomberg. [8] In November 2017, Eckert re-acquired Sprout Pharmaceuticals from Valeant for "almost nothing", according to Bloomberg. Former proposed but abandoned trade names of flibanserin include Ectris and Girosa, and its former developmental code name was BIMT-17. [14], Flibanserin acts as a full agonist in the frontal cortex and the raphe dorsalis, but only as a partial agonist in the CA3 region of the hippocampus[15] of the 5-HT1A receptor (serotonin receptor) (Ki = 1 nM in CHO cells, but only 15–50 nM in cortex, hippocampus and dorsal raphe)[2] and, with lower affinity, as an antagonist of the 5-HT2A receptor (Ki = 49 nM) and antagonist or very weak partial agonist of the D4 receptor (Ki = 4–24 nM). Just Leave That to Me", "Woman behind female libido drug launches 'Pinkubator' for women-focused businesses", "CEO of company behind Addyi says female sexuality is about biology, not just psychology", "Company Overview of Slate Pharmaceuticals, Inc", "The woman behind 'female Viagra' sold her company for $1 billion — that's when everything fell apart", "How To Make Millions Off Your Exit: 7 Entrepreneurs Worth Over $2 Billion Explain", "How I Get It Done: Cindy Whitehead, the Creator of 'Female Viagra, "Exclusive: The Woman Behind the 'Female Viagra' Has a New Venture", "Philly startup creates new pregnancy test", https://en.wikipedia.org/w/index.php?title=Cindy_Eckert&oldid=982521653, Articles which use infobox templates with no data rows, Creative Commons Attribution-ShareAlike License, This page was last edited on 8 October 2020, at 17:37. By modulating serotonin and dopamine activity in certain parts of the brain, flibanserin may improve the balance between these neurotransmitter systems in the regulation of sexual response.[23][24]. Jolly E, Thorp J, Clayton AH, et al. [51], FC(F)(F)c4cc(N3CCN(CCN2c1ccccc1NC2=O)CC3)ccc4, InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28), 1-(2-{4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2. During those years she lived overseas where her father Fred Eckert served as a US Ambassador to Fiji. The Pink Ceiling's incubator - dubbed The Pinkubator - is based in Raleigh, NC. Flibanserin was originally developed as an antidepressant,[25][26] before being repurposed for the treatment of HSDD. [11][12], To date, The Pink Ceiling has invested in eleven start-ups, with public announcements on their involvement with Undercover Colors (a company that is developing wearable nail tech to detect the presence of a date rape drug in drinks),[8] Lia Diagnostics (which produces a flushable pregnancy test),[13] Intuitap (which has a medical device aimed to streamline the spinal tap procedure),[1] and Pursuit (which is developing a patented technology to improve four different aspects of sleep)[14], The Pink Ceiling's affiliated incubator, called the “Pinkubator” because of its female focus, is located in Raleigh, North Carolina. [22] Various neurotransmitters, sex steroids, and other hormones have important excitatory or inhibitory effects on the sexual response. SECTOR . Bloomington, IN:Indiana University press. Sprout Pharmaceuticals Careers ke a waterline under the stars, her eyes It is as deep as a nebulous nebula, like a phantom that is incompatib. [4] She graduated from Marymount University in Virginia. [28] In 2010 the FDA issued a Complete Response Letter, stating that New Drug Application could not be approved in its current form. [8][9], Flibanserin is used for hypoactive sexual desire disorder among women. The Agency agreed to call a new Advisory Committee meeting to consider whether the risk-benefit ratio of flibanserin was favorable after this additional data was obtained. [12], Women's overall feeling of improvement was small to none. [11][12], To date, The Pink Ceiling has invested in eleven start-ups, with public announcements on their involvement with Undercover Colors (a company that is developing wearable nail tech to detect the presence of a date rape drug in drinks),[8] Lia Diagnostics (which produces a flushable pregnancy test),[13] Intuitap (which has a medical device aimed to streamline the spinal tap procedure),[1] and Pursuit (which is developing a patented technology to improve four different aspects of sleep)[14], The Pink Ceiling's affiliated incubator, called the “Pinkubator” because of its female focus, is located in Raleigh, North Carolina. [5], "This Entrepreneur Who Sold Her Company for $1 Billion Wants You to Throw Out the Unwritten Rules That Hold You Back", "Valeant Gives $1 Billion Female Libido Pill Back to Old Owners", "Cindy Whitehead: No Nickname? [10], Eckert launched the Pink Ceiling in order to improve access to capital for female-led start-ups. Sprout Pharmaceuticals, Inc. provides health care products and services. Development by Boehringer Ingelheim was halted in October 201 You should consult with a medical professional if you have any questions about your health. Valeant Pharmaceuticals bought Sprout, maker of 'female Viagra' pill Addyi, for $1 billion. Diagnostic and Statistical Manual of Mental Disorders, National Council of Women's Organizations, Association of Reproductive Health Professionals, "Addyi™ (flibanserin) Tablets, for Oral Use. Eckert was featured on the cover of Entrepreneur Magazine's Women to Watch issue in January 2016. [6] Prior to founding Sprout, Eckert co-founded Slate Pharmaceuticals in 2007. The letter cited several concerns, including the failure to demonstrate a statistical effect on the co-primary endpoint of sexual desire and overly restrictive entry criteria for the two Phase 3 trials. [2][20] Flibanserin also has low affinity for the 5-HT2B receptor (Ki = 89.3 nM) and the 5-HT2C receptor (Ki = 88.3 nM), both of which it behaves as an antagonist of. All rights reserved. Bausch Health Companies Inc. (formerly Valeant Pharmaceuticals) is a multinational specialty pharmaceutical company based in Laval, Canada.It develops, manufactures and markets pharmaceutical products and branded generic drugs, primarily for skin diseases, gastrointestinal disorders, eye health, and neurology.Bausch Health owns Bausch & Lomb, a supplier of eye health products. Onset of Efficacy of Flibanserin in Premenopausal Women with Hypoactive Sexual Desire Disorder. According to a New York Times profile piece, she attended a different school each year from the fourth grade through the twelfth. [16] As such, flibanserin has been described as a norepinephrine–dopamine disinhibitor (NDDI). [16][17][18][19] Despite the much greater affinity of flibanserin for the 5-HT1A receptor, and for reasons that are unknown (although it might be caused by the competition with endogenous serotonin), flibanserin occupies the 5-HT1A and 5-HT2A receptors in vivo with similar percentages. [39], Other organizations supporting the approval of flibanserin included the National Council of Women's Organizations, the Black Women’s Health Imperative, the Association of Reproductive Health Professionals, National Consumers League, and the American Sexual Health Association. The campaign emphasized that several approved treatments for male sexual dysfunction exist, while no such treatment for women was available. Daily startup and blockchain data-wiki with interviews, Q&A's & discussions about funding rounds & investors. Powered and implemented by Interactive Data Managed Solutions. Oral presentation at the 58th Annual Clinical Meeting of The American College of Obstetricians and Gynecologists, May 2010.

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