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Arena's internally discovered drug, BELVIQ® (lorcaserin HCl), is approved in the United States, and Arena is focused on discovering, developing and commercializing additional drugs to address unmet medical needs. SAN DIEGO, Jan. 7, 2015 /PRNewswire/ -- Arena Pharmaceuticals, Inc. (NASDAQ: ARNA) today announced top-line results from a Phase 1b multiple ascending dose clinical trial for APD334, an oral drug candidate that targets the sphingosine 1-phosphate subtype 1 (S1P1) receptor for the potential treatment of autoimmune diseases. December 18, 2013 "The advancement of this promising drug candidate further demonstrates Arena's focused expertise in discovering and developing innovative drug candidates targeting G protein-coupled receptors that have the potential to improve health.".

1101 Sixth Street SW, Washington, DC 20024 T 202-554-9066 F 202-488-4056 www.arenastage.org ARENA STAGE Molly Smith Artistic Director Edgar Dobie … APD334 is a potent and selective, orally available investigational drug candidate that targets the S1P1 receptor. 1 0 obj <>/Metadata 2756 0 R/ViewerPreferences 2757 0 R>>

In the Phase 1b clinical trial, APD334 demonstrated a dose-dependent effect on lymphocyte count lowering in blood, with mean decreases from baseline of up to 69%. By isolating lymphocytes in lymph nodes, fewer immune cells are available in the circulating blood to effect tissue damage. (@�&� '�ާen�\��4�SiR E�'����Q�%�J�j(k�k���y�>�]�:0�1! stream

<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 14 0 R 15 0 R 34 0 R 35 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> There were no discontinuations for adverse events, and no serious adverse events were observed. endobj �5�p�A�&hu���t(�*��BW��Wx�Q��l����ۗ�H:���OV3.���@.�ڻ����Մ0_ ��m_\�K�5>2t�L�}Q��+Y FGJc|h��|xե _���҂�\��M���* �� =�J\��₩�`���?d�a.Y�_-/X+ c|��t��ktM�/�����vd҂8�%��V� <> The world of Esperia awaits you. All images are owned or licensed by Arena Pharmaceuticals and may not be downloaded or reproduced. Arena Pharmaceuticals' Presence at United European Gastroenterology Week Strengthens Ongoing Commitment to the Gastrointestinal Disease Community, Arena Pharmaceuticals Completes Full Enrollment of Olorinab Phase 2 CAPTIVATE Trial for Abdominal Pain in Irritable Bowel Syndrome, Arena Pharmaceuticals Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4), Arena Pharmaceuticals to Present at the Jefferies Virtual Next Generation IBD Therapeutics Summit, Arena Pharmaceuticals Announces First Subject Dosed in ELEVATE UC 12 Global Phase 3 Trial Evaluating Etrasimod in Ulcerative Colitis, Arena Pharmaceuticals to Participate in Upcoming Investor Conferences, Arena Pharmaceuticals Announces First Subject Dosed in Phase 2 Trial Evaluating Etrasimod in Alopecia Areata, Arena Reports Second Quarter Financial Results with Strong Liquidity Position, and Maintained Pipeline Progress Over the Quarter, Arena Pharmaceuticals to Release Second Quarter 2020 Financial Results and Provide Corporate Update on August 5, 6154 Nancy Ridge Drive San Diego, CA 92121, One Beacon Street, Floor 28, Boston, MA 02108. Your source for research and ideas to expand high quality learning and enrichment opportunities. A, HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American.

Brussels/London - September 3, 2019. Autoimmune diseases, such as multiple sclerosis, psoriasis, ulcerative colitis, Crohn's disease and rheumatoid arthritis, are characterized by an inappropriate immune response against substances and tissues that are normally present in the body.

"Based on these impressive results, we plan to expedite APD334 into Phase 2 clinical trials for ulcerative colitis and Crohn's disease," said Jack Lief, Arena's President and Chief Executive Officer. %��ȑ�7&x�� Craig M. Audet, Ph.D., Senior Vice President, Operations & Head of Global Regulatory Affairs, Cision Distribution 888-776-0942 A classic RPG with stunning artistic beauty. Radisson Hotel Group is delighted to announce the signing of the Radisson RED London Greenwich in the UK. Such forward-looking statements include statements about the advancement, investigation, therapeutic indication, use, safety, efficacy, mechanism of action, and potential of APD334, including as a potential treatment for one or more autoimmune diseases; the significance of the trial results for APD334, including with respect to lymphocyte lowering and safety; the significance of lymphocyte lowering and reducing the immune and/or inflammatory response; expediting the development of APD334, including future trials and investigated indications; Arena's expertise in discovering and developing drug candidates that have the potential to improve health; embracing the challenge of improving health; seeking to bring innovative medicines to patients; and Arena's focus, plans, goals, strategy, expectations, research and development programs, and ability to discover and develop compounds and commercialize drugs. 10/2019: 160. Factors that could cause actual results to differ materially from the forward-looking statements include, but are not limited to, the following: top-line results are not comprehensive and are based on a preliminary analysis of then available data, and findings and conclusions related to the trial are subject to change following a more comprehensive review of the data; APD334 may not be developed, approved for marketing or commercialized for any disease or condition; risks related to commercializing drugs, including regulatory, manufacturing, supply and marketing issues and the availability and use of BELVIQ; cash and revenues generated from BELVIQ, including the impact of competition; Arena's revenues will be based in part on estimates, judgment and accounting policies, and incorrect estimates or disagreement regarding estimates or accounting policies may result in changes to Arena's guidance or previously reported results; the timing and outcome of regulatory review is uncertain, and BELVIQ may not be approved for marketing when expected or ever in combination with another drug, for another indication or using a different formulation or in any other territory for any indication; regulatory decisions in one territory may impact other regulatory decisions and Arena's business prospects; government and commercial reimbursement and pricing decisions; risks related to relying on collaborative arrangements; the timing and receipt of payments and fees, if any, from collaborators; the entry into or modification or termination of collaborative arrangements; unexpected or unfavorable new data; nonclinical and clinical data is voluminous and detailed, and regulatory agencies may interpret or weigh the importance of data differently and reach different conclusions than Arena or others, request additional information, have additional recommendations or change their guidance or requirements before or after approval; data and other information related to any of Arena's research and development may not meet regulatory requirements or otherwise be sufficient for (or Arena or a collaborator may not pursue) further research and development, regulatory review or approval or continued marketing; Arena's and third parties' intellectual property rights; the timing, success and cost of Arena's research and development; results of clinical trials and other studies are subject to different interpretations and may not be predictive of future results; clinical trials and other studies may not proceed at the time or in the manner expected or at all; having adequate funds; and satisfactory resolution of litigation or other disagreements with others. <> %PDF-1.7 Discovered by Arena, APD334 has therapeutic potential in autoimmune diseases. 2 0 obj afk and chill.

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